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Margolles engages in fieldwork-driven artmaking in the streets of border cities in northern Mexico, such as Ciudad Juárez, whose location in economic relationship to the United States has ushered in decades of conflict due to organized crime. Working closely with communities who are precluded from access to systems of social care, Margolles explores the relationship between violence and marginality, especially in light of gender. Her methodical research develops into object-based interventions: photographs of trans sex workers, many of whom are now dead, standing in the ruins of demolished nightclubs where they once worked, or posters with the faces of missing women affixed to glass panels that rattle to the sound of a train carrying manufactured goods from Juárez to El Paso. Exhibited internationally, her works underscore the influences of global trade and economic policy on conflict in Latin America.